This guide is developed primarily for national and regional Country Coordinating Mechanism members. In addition, it may be used as a reference document by facilitators while orienting CCM members, policymakers and representatives of Key Populations and civil society in the CCMs. It may also be used by CCM Secretariats to train Key Populations, other Civil Society representatives and new CCM members. Ideally, Civil Society and Key Population representatives could use it to lead CCM orientations. Secondary users may include Technical Assistance providers who wish to guide programmes to understand, design, and correctly use Community-Led Monitoring (CLM) to inform CCM oversight and national strategic review processes. The Global Fund recommends that CLM be included in all Global Fund grants to maximize their impact, quality, equity, and coverage, while also responding to human rights, gender, and other barriers.